Ankle problems can be caused by a variety of things including: ankle instability, arthritis, gout, tendinitis, fracture, nerve compression (tarsal tunnel syndrome), infection and poor structural alignment of the leg or foot.

Ankle Sprain

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Unlike ankle strains - which affect the muscles - an ankle sprain is an injury to ligaments in the ankle. Some ankle sprains are much worse than others.
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Osteochondritis

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Osteochondritis are lesions that usually cause pain, inflammation, and stiffness of the ankle joint. This can affect all age groups and is usually caused by a twisting-type injury to the ankle.
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